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Synthesis of certain tricyclic systems containing a bridgehead nitrogen

R. S. Budhram

Synthesis of certain tricyclic systems containing a bridgehead nitrogen

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Published .
Written in English


Edition Notes

Thesis(Ph.D.) - Loughborough University of Technology 1978.

Statementby R. S. Budhram.
ID Numbers
Open LibraryOL19629093M

Cycloisomerization of 1,n-enynes and diynes is a powerful method in organic synthesis to access heterocyclic compounds and has drawn increasing attention from organic chemists. In this paper, we attempted to summarize our recent results on the transition metal-catalyzed cycloisomerization to synthesize five or six-membered heterocyclic compounds using 1,n-enynes and diynes having a Cited by: / Nitrogen bridgehead compounds. Part Cyclization of 2-(2- pyridylaminomethylene)succinates in ethanolic sodium ethoxide. Part 2. Michael addition of pyridyldihydropyrrolones. In: Journal of the Chemical Society, Perkin Transactions 1. ; No. 7. pp. Cited by: 4. Formation of tricyclic cyclopropylamines of type 13 can be arrested when the nitrogen-assisted elimination of the titanium alkoxide moiety from the corresponding tricyclic intermediate would form an iminium ion with a bridgehead double bond that would violate Bredt's rule. 8 In these cases, hydrolysis of the intermediates with water without addition of Et 2 O•BF 3 leads to carbocyclic amino. Keywords: Synyhesis, Mass spectra, nitrogen heterocycles, salycylaldazine derivatives. _____ INTRODUCTION Many publications report the synthesis of different heterocyclic compounds using cyanoacetic acid hydrazide as key starting material. The biological properties of some heterocyclic compounds were prepared from cyanoaceticAuthor: Haya A. Abubshait.

Synthesis of bioactive nitrogen-containing heterocycles via aryne methodologies by Yuesi Fang A dissertation to the graduate faculty in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Major: Organic Chemistry Program of Study Committee: Richard C. Larock, Co-Major Professor George A. Kraus, Co-Major Professor.


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Synthesis of certain tricyclic systems containing a bridgehead nitrogen by R. S. Budhram Download PDF EPUB FB2

Heterocyclic system containing bridgehead nitrogen atom: synthesis and pharmacological activities of some substituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles Author links open overlay panel V. Mathew a J. Keshavayya b V.P. Vaidya bCited by: The name of those ring systems that are treated in this chapter are indicated in italics in Figure 3, Figure 4, Figure 5, Figure first members of pyrido[2,1-j][3,1]benzoxazine ring system were synthesized during the rewied period, indicating in bold, as shown in Figure ad: Download full-size image Figure ew of the known bicyclic ring systems containing one bridgehead Cited by: 3.

T1 - Synthesis of fused bicyclic systems with nitrogen atom at the bridgehead, including indolizidines and quinolizidines. AU - Pepe, Antonella. AU - Pamment, Michael.

AU - Georg, Gunda I. AU - Malhotra, Sanjay V. PY - /5/6. Y1 - /5/6Cited by: Here, all aspects of the topic are presented in a compact manner. The book is clearly structured, and divided into two sections -- asymmetric synthesis of heterocycles containing only one nitrogen and that of those with more than one nitrogen as a heteroatom -- such that the.

of alkaloids containing quinolizidine, quinolizine, or quinolizinium structural fragments are given in structures 6– Simple quinolizidine alkaloids Lupinine 6 N H OH N Me O H Myrtine 7 I 8 N OMe OMe H OH N NH O Cytisine 9 Tricyclic quinolizidine– piperidine alkaloids Bicyclic Systems with One Bridgehead (Ring Junction) Nitrogen Atom.

Papers on the synthesis of nitrogen-containing heterocyclic compounds by ring enlargement reactions based on the formation of an annelated cyclopropane ring by intramolecular alkylation followed by cleavage of the zero bridge in the obtained [n] bicyclic systems are by: 7.

Synthesis of Tricyclic N-Bridgehead Compounds (quinazolinones and diamines) Scheme 3 shows the reaction conditions for reduction of the imine group of compounds 32 and 34 to the corresponding amines using sodium cyanoborohydride in ethanol at room temperature for 24 h to yield compounds 39 respectively.

27Cited by: Buy Asymmetric Synthesis of Nitrogen Heterocycles on FREE SHIPPING on qualified orders. Synthesis, Characterization, Anti-Microbial and Anti-Cancer Activity of Novel Heterocyclic System Containing Bridgehead Nitrogen Atom. BRAMANIAN*, ADITYA REDDY, DA, THI and A, An attempt was made to utilize the concept of bio-isosterism for the synthesis of 3-amino2- mercapto5, 6, 7.

Paperback: 96 pages Publisher: LAP LAMBERT Academic Publishing ( ) Language: English ISBN ISBN Product Dimensions: x x inches Shipping Weight: ounces (View shipping rates and policies) Customer Reviews: Be the first to write a review Amazon Best Sellers Rank: #13, in Books (See Top in Books)Author: Anita Mali, Aravind Burungale, Chandrakant Jadage.

BRIDGEHEAD NITROGEN HETEROCYCLIC SYSTEMS: FACILE SYNTHESIS, BIOACTIVITY OF SOME NEWER DERIVATIVES OF 1-SUBSTITUTED BENZYLIDENE HYDRAZINO TETRAZOLO [1, 5-a] QUINOXALINES. Umarani N* and Ilango K Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM University, Kattankulathur -Kancheepuram District, Tamil Nadu, India.

Search this site Search this site. Contact & Service. Contact. Contact form; Contact persons; Sites and opening hours. In this review, we systematize data on methods for synthesis of nitrogen-containing heterocyclic compounds cyclocondensation of α-haloketones with different compounds.

This is a preview of subscription content, log in to check by: 2. synthesis of nitrogen-containing heterocycles, including 3-sustituted azepanes and 1-azoniapropellanes.

A general synthesis of 3-sustituted azepanes has been developed using nitroalkenes as building blocks. A novel, vinylogous, conjugate addition reaction of an. ii reduction of 5-subsituted 2-pyrrolinones 97. conclusions and considerations for the future. chapter 5 – experimental. general experimental.

miscellaneous pyrrole synthesis. chapter 2 experimental. experimental for chapter 3. experimental for chapter 4. reference list. part 2: the strain driven rearrangement of cyclopropenyl. Nowadays, the alarming rates of emerging and re-emerging microbial threats coupled with increasing antituberculosis, antibacterial and antifungal resistance; particularly in regard to multi drug-resistant microbes are major concerns to the public health as well as scientific communities worldwide.

A search for new antimicrobial compounds with a more selective activity and lower toxicity. polycyclic nitrogen-containing heterocycles.7 ALKALOIDS AND THE SYNTHESIS OF NITROGEN HETEROCYCLES The only defining structural feature of any alkaloid is a nitrogen atom set in a particular carbon framework.

Many of the alkaloids contain complex polycyclic core. The Synthesis of Novel Nitrogen Containing Heterocycles A thesis submitted in (partial) fulfillment of the requirements for the award of the degree DOCTOR OF PHILOSOPHY From UNIVERSITY OF WOLLONGONG By Arife YAZICI, Org.

Chem. (Hons., ) Supervisor: Prof. Stephen G. Pyne School of Chemistry January Some New Nitrogen Bridgehead Heterocyclic Cyanine Dyes A.

KORAIEM, H. SHINDY, and R. ABU EL-HAMD Department of Chemistry, Aswan Faculty of Science, Aswan, Egypt Received 21 July Accepted for publication 30 December New monomethine, trimethine, and azomethine cyanine dyes of pyrazolo^o'iSjôJÍpyrazinio/l^.

Under the conditions of Vilsmeier-Haack formylation, nitrogen bridgehead ring systems containing a 6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidinone moiety (which can isomerize into a tautomeric.

Synthesis of N-alkaloidacyl derivatives of phenothiazine. tricyclic systems occupy a The synthesis of a new series of alkylxanthine analogs containing a bridgehead nitrogen atom is.

"Synthesis and characterization of macrocyclic complexes containing N, O or S as biting centers" is the result of original researches carried out by IMs.

Shaltira Khatoon under my supervision and is suitable for submission for the award of the Ph.D. degree of Aligarh Muslim University, Aligarh, India. (Prof. IVIohammad Shakir). The general aims of this work were to develop routes to new nitrogen-containing bridged systems and to study the properties of these and related known systems.

Firstly attention was directed to the synthesis of some new 3-aza-naphthothiadiazolophanes by a ring destruction involving the cyanogen bromideand chloroformate ester-mediated cleavage of a central benzylic carbon-nitrogen bond in Author: Wasna Jaturonrusmee. Pyrazoles are the nitrogen containing aromatic heterocycles characterized by a five-membered ring structure composed of three carbon atoms and two nitrogen atoms at adjacent positions.

They basically belong to azole family and seem to be derived from pyrrole through substitution of a carbon at position-2 by nitrogen atom.

File Size: KB. Huang, X., Li, X., Xie, X. et al. Catalytic asymmetric synthesis of a nitrogen heterocycle through stereocontrolled direct photoreaction from electronically excited state.

Nat Cited by: Book Series Help; Contact Portal SYNTHESIS Full-text search On the Knorr Synthesis of 6-Bromomethylquinolin-2(1H)-one Full Text HTML PDF ( kb) Catalysis in the Diastereoselective Two-Step Synthesis of Tricyclic Systems Full Text.

Heterocyclic Systems with Bridgehead Nitrogen Atoms. Part I Mosby W.L. You can write a book review and share your experiences. Other readers will always be interested in your opinion of the books you've read. Whether you've loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right.

The chemistry of nitrogen-containing macrocyclic compounds started over years ago when Bayer prepared tetraazaquaterene, that is calix[4]pyrrole, (1) in 1b Hinsberg and Kessler in prepared similar nitrogen-containing macrocycles.

2 Cyclic tetraamines 2 and. The six chapters of this dissertation exemplify the application of aryne chemistry in medicinally-relevant, nitrogen-containing heterocycle synthesis.

The arynes discussed in this dissertation are generated from Kobayashi's aryne precursors that leads to novel synthetic methodology. Chapter 1 begins by detailing the overall organization of this dissertation and follows with a brief review of Author: Yuesi Fang.

Manifestations of Bridgehead−Bridgehead Interactions in the Bicyclo[]pentane Ring System. The Journal of Organic Chemistry64 (8), DOI: / by:   hence it is also known as imidazo[1,2-a]pyridine.2 Several procedure for their synthesis have been extensively studied. Such studies have been stimulated by various promising applications, especially in the case of bridgehead nitrogen containing fused heterocyclic entities.

The constitution of. Back to Table of Contents. G1 A Novel Synthesis of Nitrogen Heterocycles by Ring-Opening Reactions of Pyridinium Salts. Christopher D. Vanderwal, University of California (Irvine). The ring opening reaction of pyridinium salts dates back over a century. The synthesis of novel nitrogen containing heterocycles Arife Yazici University of Wollongong Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.

Research Online is the open access institutional repository for the University of Wollongong. The basics Earth’s atmosphere is about 78% nitrogen making it the largest pool of nitrogen Nitrogen is essential for many biological processes; it is in all amino acids, is incorporated into proteins, and is present in the bases that make up nucleic acids, such as DNA and RNA In plants, much of the nitrogen is used in chlorophyll molecules whichFile Size: 1MB.

Keywords:Nitrogen heterocyclic N-oxides, cyclization, mechanism, synthesis. Abstract:Nitrogen heterocyclic N-oxides attract enormous interest in synthetic chemistry, medicinal chemistry, functional materials and energetic materials.

Cyclization reaction turns out to be an important and highly rewarding protocol for the construction of N Cited by: 5. Nitrogen-containing compounds are important chemical entities, many of which show unique bioactivity.

In view of this their efficient synthesis is an important issue in the development of pharmaceutically active molecule. However, the handling of highly-polar nitrogen-containing compounds is often problematic, and furthermore the propensity of.

The synthesis, characterization, and energetic properties of diazido heteroaromatic high-nitrogen C−N compound, 3,6-diazido-1,2,4,5-tetrazine (DiAT), are reported. Its normalized heat of formation (NΔHf), experimentally determined using an additive method, is shown to be the highest positive NΔHf compared to all other organic molecules.

The unexpected azido-tetrazolo tautomerizations and. Synthetic Studies of Nitrogen Containing Heterocycles, Particularly Pyrazole and Benzotriazine Derivatives This thesis will mainly focus on the chemistry of nitrogen containing heterocyclic compounds, particularly pyrazole and benzotriazine and related ring systems to these The second part features the synthesis of 3-substituted Cited by: 1.

devoted to tricyclic systems containing an azepine ring along with two other other rings that can be either carbocyclic or heterocyclic. This category includes no fewer than different heterocyclic systems, ranging from oxireno[4[2]benzazepines (a 3,6,7-system) to benzo[elcyclooct[b]azepines (a, 6,7,8-system).

The Synthesis and Biological Evaluation of Novel Nitrogen containing 6 and 7 membered ring Heterocyclic Compounds Idhnan Abas Hussain January Synthesis of Ring Substituted 3,5-dibenzylidenemethyl piperidinones, 3.

Synthesis and Identification of Mono and Bicyclic Compounds Containing Dinitrogen Atoms as Anesthetic Dr. Nagham Mahmood Aljamali *1 1. Department of Chemistry, Faculty of Science, University of Kufa, Iraq. Issue 1 Journal of Scientific & Innovative Research 23 [7] 2-(2-hexanone–thiazolidine).

(C=N) (O=C–CH 3)ketone.Synthesis of Nitrogen-Containing Heterocycles via Ring-Closing Ene-Ene and Ene-Yne Metathesis Reactions: An Easy Access to 1- and 2-Benzazepine Scaffolds and Five- and Six-Membered Lactams Erica Benedetti, Michela Lomazzi, Francesco Tibiletti, Jean-Philippe Goddard, Louis Fensterbank, Max Malacria, Giovanni Palmisano, Andrea Penoni*.Results and Discussion.

The key intermediate, thiolactone 5 (Scheme 1), was synthesized using a four-step reaction developed by Wang and Salvino [].The N-alkylated 5-substituted isatin/isatin intermediates 6 were obtained in a one-step reaction in good to excellent yields by the reported procedure [].Thus, with 5 and 6 in hand, synthesis of the desired hybrids 3 was subsequently by: 6.